A. Del Rio Flores, H. Phan, S. Lynch, L. Liu, and C. Khosla (2026). “Mechanistic Analysis of Programmed Iteration by Module 5 of the Nocardiosis-Associated Polyketide (NOCAP) Synthase,” Biochemistry. https://doi.org/ 10.1021/acs.biochem.5c00718

 

Kishore, S.; Privalsky, T. M.; Del Rio Flores, A.; Lynch, S. R.; Khosla, C. (2025). Self‑Resistance Guided Discovery of a Hybrid Polyketide‑Peptide Antibiotic from Vibrio ruber. J. Am. Chem. Soc. https://doi.org/10.1021/jacs.5c07625.

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​Del Rio Flores, A., & Khosla, C. (2024). Characterization of the Flavin-Dependent monooxygenase involved in the biosynthesis of the Nocardiosis-Associated polyketide. Biochemistry, 63(21), 2868–2877. https://doi.org/10.1021/acs.biochem.4c00480

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Del Rio Flores, A., Zhai, R., Kastner, D. W., Seshadri, K., Yang, S., De Matias, K., Shen, Y., Cai, W., Narayanamoorthy, M., B, N., DO, Xue, Z., Marzooqi, D. A., Kulik, H. J., & Zhang, W. (2024). Enzymatic synthesis of azide by a promiscuous N-nitrosylase. Nature Chemistry. https://doi.org/10.1038/s41557-024-01646-2

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The Atomwise AIMS Program. AI is a viable alternative to high throughput screening: a 318-target study. Sci Rep 14, 7526 (2024). https://doi.org/10.1038/s41598-024-54655-z

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Kishore, S., Del Rio Flores, A., Lynch, S. R., Yuet, K. P., & Khosla, C. (2024). Discovery and characterization of the fully decorated Nocardiosis-Associated polyketide natural product. Journal of the American Chemical Society, 146(6), 4212–4220. https://doi.org/10.1021/jacs.3c13670

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Del Rio Flores, A., Zhai, R., & Zhang, W. (2024). Isonitrile biosynthesis by non-heme iron(II)-dependent oxidases/decarboxylases. Methods in Enzymology on CD-ROM/Methods in Enzymology, 143–172. https://doi.org/10.1016/bs.mie.2024.06.002​

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​Del Rio Flores, A., Narayanamoorthy, M., Cai, W., Zhai, R., Yang, S., Shen, Y., Seshadri, K., De Matias, K., Xue, Z., & Zhang, W. (2023). Biosynthesis of Isonitrile Lipopeptide Metallophores from Pathogenic Mycobacteria. Biochemistry, 62(3), 824–834. https://doi.org/10.1021/acs.biochem.2c00611​

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Antonio, D. R. F. (2023). Biosynthesis of unusual synthons in natural products. https://escholarship.org/uc/item/21x7055c​

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Del Rio Flores, A., Barber, C. C., Narayanamoorthy, M., Gu, D., Shen, Y., & Zhang, W. (2022). Biosynthesis of Isonitrile- and Alkyne-Containing natural products. Annual Review of Chemical and Biomolecular Engineering, 13(1), 1–24. https://doi.org/10.1146/annurev-chembioeng-092120-025140

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Del Rio Flores, A., Kastner, D. W., Du, Y., Narayanamoorthy, M., Shen, Y., Cai, W., Vennelakanti, V., Zill, N. A., Dell, L. B., Zhai, R., Kulik, H. J., & Zhang, W. (2022). Probing the mechanism of isonitrile formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase. Journal of the American Chemical Society, 144(13), 5893–5901. https://doi.org/10.1021/jacs.1c12891

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Zhang, H., Goh, N.S., Wang, J.W. et al. Nanoparticle cellular internalization is not required for RNA delivery to mature plant leaves. Nat. Nanotechnol. 17, 197–205 (2022). https://doi.org/10.1038/s41565-021-01018-8

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Del Rio Flores A., Twigg, F.F., Du, Y. et al. Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore. Nat Chem Biol 17, 1305–1313 (2021). https://doi.org/10.1038/s41589-021-00895-3​

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​Jonnalagadda, R., Del Rio Flores, A., Cai, W., Mehmood, R., Narayanamoorthy, M., Ren, C., Zaragoza, J. P., Kulik, H. J., Zhang, W., & Drennan, C. L. (2021). Biochemical and crystallographic investigations into isonitrile formation by a nonheme iron-dependent oxidase/decarboxylase. Journal of Biological Chemistry, 296, 100231. https://doi.org/10.1074/jbc.ra120.015932

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​Li, J. S., Du, Y., Gu, D., Cai, W., Green, A., Ng, S., Leung, A., Del Rio Flores, A., & Zhang, W. (2020). Discovery and Biosynthesis of Clostyrylpyrones from the Obligate Anaerobe Clostridium roseum. Organic Letters, 22(21), 8204–8209. https://doi.org/10.1021/acs.orglett.0c02656

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​Huang, Y.-B., Luo, Y.-J., Rio Flores, A. D., Li, L.-C., & Wang, F. (2020). N-aryl pyrrole synthesis from biomass-derived furans and arylamine over lewis acidic hf-doped mesoporous SBA-15 catalyst. ACS Sustainable Chemistry & Engineering, 8(32), 12161–12167. https://doi.org/10.1021/acssuschemeng.0c03578​​

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Skyrud, W., Del Rio Flores, A., & Zhang, W. (2020). Biosynthesis of Cyclohexanecarboxyl-COA highlights a promiscuous Shikimoyl-COA synthetase and a FAD-Dependent dehydratase. ACS Catalysis, 10(5), 3360–3364. https://doi.org/10.1021/acscatal.0c00406

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Del Rio Flores A., Twigg, F.F., Cai W., et al. Facile Discovery and Quantification of Isonitrile Natural Products via Tetrazine-Based Click Reactions. Anal. Chem. 2020, 92, 1, 599–602. https://doi.org/10.1021/acs.analchem.9b05147

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Ren, Y., Bai, Y., Zhang, Z., Cai, W., & Del Rio Flores, A. (2019). The Preparation and Structure Analysis Methods of Natural Polysaccharides of Plants and Fungi: A Review of Recent Development. Molecules, 24(17), 3122. https://doi.org/10.3390/molecules24173122

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​Huang, Y.-B., Cai, W., Del Rio Flores, A. D. R., Twigg, F. F., & Zhang, W. (2020). Facile discovery and quantification of isonitrile natural products via tetrazine-based click reactions. Analytical Chemistry, 92(1), 599–602.​